Drug Reference

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Naloxone Hydrochloride, Pentazocine Hydrochloride Oral tablet

Additional titles for this drug

Pentazocine Hydrochloride/Naloxone Hydrochloride 50mg-0.5mg Tablet, Pentazocine Hydrochloride/Naloxone Hydrochloride 50mg-5mg Tablet, Talwin NX 50mg-0.5mg Tablet

What is this medicine?

PENTAZOCINE (pen TAZ oh seen) is a pain reliever. It is used to treat moderate to severe pain. It also contains naloxone, which is used to prevent the misuse of this medicine.

How should I use this medicine?

Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 12 years of age for selected conditions, precautions do apply.

Patients over 65 years old may have a stronger reaction and need a smaller dose.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breathing problems

  • changes in vision

  • chills, flushing, sweating

  • confusion, disoriented

  • fast, irregular heartbeat

  • feeling faint or lightheaded, falls

  • hallucinations

  • redness, blistering, peeling or loosening of the skin, including inside the mouth

  • tremors

  • trouble passing urine or change in the amount of urine

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • clumsy, unsteady

  • constipation

  • difficulty sleeping

  • headache

  • nausea, vomiting

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • butorphanol

  • buprenorphine

  • nalbuphine

This medicine may also interact with the following medications:

  • alcohol

  • antihistamines for allergy, cough and cold

  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate

  • certain medicines for depression, anxiety, or psychotic disturbances

  • medicines for sleep

  • muscle relaxants

  • narcotic medicines (opiates) for pain

  • procarbazine

  • sibutramine

  • tramadol

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children. This medicine can be abused. Keep your medicine in a safe place to protect them from theft. Do not share this medicine with anyone. Selling or giving away this medicine is dangerous and is against the law.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light.

Throw away any unused medicine after the expiration date. Discard unused medicine and used packaging carefully. Pets and children can be harmed if they find used or lost packages.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • breathing problems

  • drug abuse or addiction

  • head injury

  • if you frequently drink alcohol containing beverages

  • kidney disease

  • liver disease

  • seizures

  • an unusual or allergic reaction to pentazocine, naloxone, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Tell your doctor or health care professional if your pain does not go away, if it gets worse, or if you have new or a different type of pain. You may develop tolerance to the medicine. Tolerance means that you will need a higher dose of the medicine for pain relief. Tolerance is normal and is expected if you take the medicine for a long time.

Do not suddenly stop taking your medicine because you may develop a severe reaction. Your body becomes used to the medicine. This does NOT mean you are addicted. Addiction is a behavior related to getting and using a drug for a non-medical reason. If you have pain, you have a medical reason to take pain medicine. Your doctor will tell you how much medicine to take. If your doctor wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

There are different types of narcotic medicines (opiates) for pain. If you take more than one type at the same time, you may have more side effects. Give your health care provider a list of all medicines you use. Your doctor will tell you how much medicine to take. Do not take more medicine than directed. Call emergency for help if you have problems breathing.

This medicine will cause constipation. Try to have a bowel movement at least every 2 to 3 days. If you do not have a bowel movement for 3 days, call your doctor or health care professional.

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Medicap Pharmacy
400 1st Avenue West
Newton, IA 50208

Ph. 641-792-3528
Fx. 641-792-3526

Pharmacy Hours:

Mon-Fri: 8:30am-6:30pm
Sat: 9:00am-1:30pm
Sun: Closed

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