Drug Reference

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Perphenazine Oral tablet

Additional titles for this drug

Perphenazine 16mg Tablet, Perphenazine 2mg Tablet, Perphenazine 4mg Tablet, Perphenazine 8mg Tablet, Trilafon 16mg Tablet, Trilafon 2mg Tablet, Trilafon 4mg Tablet, Trilafon 8mg Tablet

What is this medicine?

PERPHENAZINE (per FEN a zeen) is used to treat schizophrenia. It also is used to treat severe nausea and vomiting in adults.

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your doses at regular intervals. Do not take your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. While this medicine may be prescribed for children as young as 12 years of age for selected conditions, precautions do apply.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • blurred vision

  • breast enlargement in men or women

  • breast milk in women who are not breast-feeding

  • chest pain, fast or irregular heartbeat

  • confusion, restlessness

  • dark yellow or brown urine

  • difficulty breathing or swallowing

  • dizziness or fainting spells

  • drooling, shaking

  • fever, chills, sore throat

  • involuntary or uncontrollable movements of the eyes, mouth, head, arms, and legs

  • seizures

  • stomach area pain

  • unusual bleeding or bruising

  • unusually weak or tired

  • yellowing of skin or eyes

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • difficulty passing urine

  • difficulty sleeping

  • headache

  • sexual dysfunction

  • skin rash, or itching

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • amoxapine

  • antidepressants like citalopram, escitalopram, fluoxetine, paroxetine, and sertraline

  • certain antibiotics like gatifloxacin, grepafloxacin, sparfloxacin

  • cisapride

  • clozapine

  • dofetilide

  • droperidol

  • ibutilide

  • levomethadyl

  • maprotiline

  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine

  • phenylpropanolamine

  • pimozide

  • pindolol

  • propranolol

  • sotalol

  • tricyclic antidepressants like amitriptyline, clomipramine, imipramine, nortriptyline and others

  • trimethobenzamide

  • ziprasidone

This medicine may also interact with the following medications:

  • antacids

  • medicines for colds and flu

  • medicines for hay fever and other allergies

  • prescription pain medicines

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from light. Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • blood disorders or disease

  • dementia

  • liver disease or jaundice

  • Parkinson's disease

  • uncontrollable movement disorder

  • an unusual or allergic reaction to perphenazine, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

This medicine can reduce the response of your body to heat or cold. Try not to get overheated. Avoid temperature extremes, such as saunas, hot tubs, or very hot or cold baths or showers. Dress warmly in cold weather.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

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Medicap Pharmacy
105 Lincoln Way
Ames, IA 50010

Ph. 515-232-1653
Fx. 515-232-3382

Pharmacy Hours:

Monday - Friday:
8am - 6pm
Saturday:
9am - 1pm
Sunday:
Closed

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